How does motrin affect kidneys

However, kidney patients who need to use acetaminophen habitually should be supervised by their doctors and be sure to avoid drinking alcohol while on this medicine. This includes different brands of ibuprofen, naproxen sodium and ketoprofen.

NSAIDs are usually safe for occasional use when taken as directed, but if you have known decreased kidney function, they should be avoided. These medications should only be used under a doctor's care by patients with kidney disease, heart disease, high blood pressure or liver disease or by people who are over 65 or who take diuretic medications. NSAIDs may cause an increased risk of sudden kidney failure and even progressive kidney damage. You should speak to your doctor about the best choice for you.

In addition, if you have any of the medical conditions listed in the previous question, you should only use NSAIDs under your doctor's supervision. Your doctor can check your kidneys by doing a simple blood test called a serum creatinine level. This test measures the amount of a waste product in your blood that is normally removed by your kidneys. If your kidneys are not working as well as they should, the creatinine level will be increased in your blood. The results of the serum creatinine test can be used to estimate your glomerular filtration rate GFR.

Your GFR number tells your doctor how much kidney function you have. All of them did have repeat UA on multiple occasions.

At the last followup, all patients had a normal UA. We describe fifteen inpatients that were previously healthy without a history of previous kidney conditions and developed AKI. All of our cases were non-oliguric. Two of the patients required hemodialysis.

Fourteen out of fifteen patients had at least doubling of the serum creatinine. Only one of our patients required steroid therapy as rest had decreasing serum creatinine prior to discharge from hospital. Steroid therapy has been used in AIN successfully, though no controlled trials have demonstrated consistent benefits [ 7 , 8 ].

The one patient who required steroid therapy also required hemodialysis for ten days and took six months to return to baseline renal function [ 8 ]. All patients recovered renal function; however, many patients had abnormal serum creatinine for prolonged periods; eight patients required weeks to months to normalize their renal function.

None of the patients developed a relapse of any kind of unrelated renal disease. NSAIDs are a known cause of AKI, yet as an entity they may remain under diagnosed because the kidney failure is often moderate, asymptomatic, transitory, and non-anuric [ 2 , 10 ]. Under normal physiological conditions, renal blood flow is either independent of prostaglandin synthesis or, under certain circumstances, there is activation of the renin-angiotensin system.

When circulating vasoconstrictors are released and to maintain renal blood flow, counter-regulatory prostoglandins are released [ 10 ]. NSAIDs exert antipyretic, analgesic, and anti-inflammatory effects by reducing vasodilatory prostaglandin biosynthesis [ 2 ]. Tubulointerstitial nephritis is an inflammatory pathology of renal interstitium and tubules with acute damage, edema, and can potentially heal with interstitial fibrosis [ 1 , 6 , 11 ].

Clinically, AIN resembles ATN though sometimes signs such as rash, eosinophilia, and eosinophiluria can be present [ 1 , 6 , 11 ]. It is important to recognize when AIN may be due to a drug because prolonged injury may cause permanent scarring, and withdrawal of offending agent is obligatory [ 1 , 6 , 11 ]. NSAID nephropathy caused by hypersensitivity can cause a reaction that is milder than in drug-induced AIN, probably because the offending drug inhibits the inflammatory reaction it has started itself [ 6 , 7 , 8 , 11 ].

Proteinuria can be a response to lymphokines production because of immunological responses [ 11 ]. A stronger allergic reaction results in AKI with minimal proteinuria. On the other hand, immunocompetent cells can develop to produce lymphokines and lead to heavy proteinuria. Immune complexes are formed secondary to the increased glomerular permeability due to a hyperactive immune system [ 11 ].

Unless serial serum creatinine values are obtained, AKI can be missed [ 6 , 7 ]. Prompt diagnosis of NSAID induced AKI with prompt discontinuation of the offending agent will usually reverse the condition within one week, typically within 72 to 96 hours [ 5 ].

In inpatient settings, clinicians tend to recheck serial creatinine if there is oliguria. The main indication for their use is pain or fever. Most of the children described in our case series were between the ages of fourteen and nineteen, and the majority admitted to taking pain killers without medical supervision.

The fact they were not feeling well and did not consume enough fluids must have aggravated the renal side effects of NSAIDs. It is noted in these studies that moderate volume depletion caused by diarrhea and vomiting can aggravate the renal toxicity of NSAIDs.

Other researchers have found that patients who were administered a high daily dose of NSAIDs had a greater risk of developing AKI than patients who were administered low to medium doses [ 13 ]. Due to the retrospective nature of our study, it has limitations. Though all children admitted to taking NSAIDs, such as ibuprofen and naproxen, the exact dose and duration could not be scientifically confirmed. As OTC products are usually regarded safe and inadequate monitoring of side effects in children consuming NSAIDs suffering from intravascular volume contraction is a real danger.

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Greenwich ; 5 — The doctor can check for possible medical problems and advise you about what medications you should take. When taken as directed, regular use of aspirin does not seem to increase the risk of kidney disease in people who have normal kidney function. However, taking doses that are too large usually more than six or eight tablets a day may temporarily reduce kidney function.

In people with kidney disease, aspirin may increase the tendency to bleed. People who already have reduced kidney function, or other health problems such as liver disease or severe heart failure, should not use aspirin without speaking to their doctor. My doctor recommended that I take an aspirin every day to prevent heart attacks.

Will this hurt my kidneys? There is no risk to the regular use of aspirin in the small doses recommended for prevention of heart attacks. Acetaminophen remains the drug of choice for occasional use in patients with kidney disease because of bleeding complications that may occur when these patients use aspirin.

However, kidney patients who need to use acetaminophen habitually should be supervised by their doctors. This includes different brands of ibuprofen, naproxen sodium and ketoprofen. NSAIDs are safe for occasional use when taken as directed.